df = pd.DataFrame(np.arange(12).reshape(3, 4), columns=['A', 'B', 'C', 'D']) >>> df    A  B   C   D 0  0  1   2   3 1  4  5   6   7 2  8  9  10  11  cols=['B', 'C'] >>> df.drop(columns = cols)  # or # df.drop(columns = ['B', 'C'])    A   D 0  0   3 1  4   7 2  8  11 

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